Sermorelin

Sermorelin is a synthetic GHRH analog that stimulates the pituitary to release endogenous growth hormone; the community runs it primarily for sleep quality and recovery, with muscle growth and fat loss as a close second use. Most users dose around 200 mcg per day, often on a 5-days-on/2-days-off schedule, while clinician protocols typically range from 200 mcg to 1 mg and suggest 3–6 month cycles. The honest limitation: the exploratory human evidence base is thinner than its reputation implies, with most trials lacking published results and all use remaining off-label. Sleep changes are the most commonly reported experience.

Half-life~12 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.91.73.83.02.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

Sermorelin has limited human evidence — 78 published studies, with 58 classified as diagnostic or mechanistic work and the remaining 20 treatment-focused studies all thin and exploratory. No registered clinical trials appear in the major registries, meaning the literature base carries no blinded trial infrastructure. A third indication is preclinical only, and none of the three mapped indications has a completed registered trial behind it.

Depthhow much
0 registered trials
Breadthhow many areas
3 indications mapped
2 thin / exploratory · 1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth87 rows captured
Human
direct clinical signal
78
Animal
translational support
8
In vitro
mechanistic support
1
HighMediumLow

Anecdotal efficacy

Sermorelin side effects

Clinical research side effects

Grouped from 21 published human studies — weighted by study count, not incidence (the papers report no rates).

Anecdotal side effects

Price

Full buying guide →
1
Bulk Peptide Supply
unknown
50 mg×10
$36.00
$0.72/mg
2
Evolvepeptides
US
50 mg
$45.00
$0.9/mg
3
High Purity Peptides
Hong Kong
100 mg×10
$100.00
$1/mg
4
Nurev Peptides
--
10 mg
$13.99
$1.4/mg
5
Uther
unknown
50 mg×10
$85.00
$1.7/mg
6
Chimera Peptides
CN
100 mg×10
$179.00
$1.79/mg

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Sermorelin dosing & protocol

How Sermorelin is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 20
Typical dose
2 mg500 µg – 4 mg
typical
0
5 mg
10 mg
15 mg
distribution of 3 reported doses · darker = more
Frequency
twice daily

Typically, doses varied from 500 µg to 4 mg (or 10–50 µg/kg) and were administered nightly, daily, or twice daily in research trials.

20 sources
Clinician practice
Doctor & published-protocol guidance · n = 3
Typical dose
300 µg200 µg – 1 mg
typical
0
5 mg
10 mg
15 mg
distribution of 5 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
twice daily
Route
subQ

In clinician practice, Sermorelin is commonly administered subcutaneously at 300 mcg once daily or up to 1 mg twice daily, with reported doses ranging from 200 mcg to 1 mg.

3 sources
Anecdotal
Community-reported real-world use · n = 30
Typical dose
200 µg10 µg – 15 mg
typical
0
5 mg
10 mg
15 mg
distribution of 39 reported doses · darker = more
Frequency
unspecified
Route
subQ
Cycle
5 days on / 2 days off · 5 reports

Community users most often administer sermorelin subcutaneously at around 200 mcg, though doses reported span from 10 mcg to 15 mg; the majority use it continuously, while a smaller subset follows a 5 days‑on/2 days‑off cycle.

30 sources

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