MK-677

MK-677 (also known as Ibutamoren or Nutrobal) is an oral ghrelin receptor agonist that raises growth hormone release, appetite, sleep and muscle growth, and it is most often taken off‑label for appetite increase and weight gain, followed by GH/IGF‑1 axis support and muscle‑building goals. Typical community use centers on a daily dose of about 10 mg (with a reported range of 5 mg–30 mg), usually taken without a set schedule, and many users follow roughly eight‑week cycles. In the registered trial program, roughly one‑third of participants withdrew, highlighting a notable tolerability concern despite the peptide’s hormonal effects.

Half-life~24 h

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsAnecdotalEfficacyAnecdotalSideEffectsPrice3.01.73.53.82.72.0

Research Evidence

Evidence shape

The evidence for MK-677 is limited, resting on two small human studies—one treatment-focused and one diagnostic/mechanistic. Across eight indications, most data come from single, exploratory trials involving a combined total of about 49 participants, with only one blinded Phase 2 study (sponsored by three different groups) posting results. One‑third of the registered trials were withdrawn, and many indications rely solely on sole, unpublished or animal‑only work, signaling a thin evidence base.

Depthhow much
6 registered trials
4 completed · 1 with posted results · combined n=49
Breadthhow many areas
8 indications mapped
6 thin / exploratory · 1 animal-only · 6 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
1 blinded with results · 3 distinct sponsors · 33% withdrawal rate · AE table from NCT00395291 · 2 linked publications on registered trials
Breadth and depth24 rows captured
Human
direct clinical signal
8
Animal
translational support
12
In vitro
mechanistic support
4
HighMediumLow

Anecdotal efficacy

MK-677 side effects

Clinical research side effects

Anecdotal side effects

Price

Full buying guide →
1
Disguisedalpha
US
102 mg
$89.99
$0.882/mg
2
Genx Peptides
US
50 mg
$74.00
$1.48/mg
3
Nootropic Source
USA
25 mg
$50.00
$2/mg
4
Soma Chems
USA
25 mg
$59.99
$2.4/mg
5
EU Peptide Shop
Europe
25 mg
$61.72
$2.47/mg
6
Moglabs
US
25 mg
$68.00
$2.72/mg

price offers can be sorted by column · 1 out-of-stock offer not shown

Some links are affiliate links. This never affects our rankings or inclusion.

1-6 of 24

MK-677 dosing & protocol

How MK-677 is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 5
Typical dose
25 mg5 mg – 25 mg
typical
0
10 mg
20 mg
30 mg
distribution of 4 reported doses · darker = more
Frequency
daily
Route
oral

In the reported research trials, MK‑677 was administered orally at doses between 5 mg and 25 mg per day, with 25 mg daily being the most frequently used amount; no specific cycling schedule was described.

5 sources
Clinician practice
Doctor & published-protocol guidance
Typical dose
—
0
10 mg
20 mg
30 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

Anecdotal
Community-reported real-world use · n = 39
Typical dose
10 mg5 mg – 30 mg
typical
0
10 mg
20 mg
30 mg
distribution of 46 reported doses · darker = more
Frequency
unspecified
Route
oral
Cycle
~8-week cycle · 2 reports

The typical dose reported was 10 mg orally, with individual reports ranging from 5 mg to 30 mg; frequency was not specified in most reports, though a few noted daily use, and only two reports described an ~8‑week cycle.

39 sources

Related peptides

CJC-1295IpamorelinHexarelinGHRP-6GHRP-2SermorelinIpamorelin / CJC-1295 BlendCapromorelinSomatropin (HGH 191AA)