MK-677

MK-677, or Ibutamoren, is an oral ghrelin-receptor agonist that stimulates growth hormone release, and the community runs it for appetite and weight gain, GH/IGF-1 support and recovery, and muscle mass and strength, where satisfaction tends to run high. People commonly take around 12 mg a day, spanning 500 mcg to 30 mg, often daily and sometimes in roughly eight-week cycles. Effects on sleep and dreams are frequently reported and mostly welcomed. Two things to know up front: there's no FDA-approved indication, so all use is off-label or compounded, and the registered trial program carried close to a 30% withdrawal rate.

Half-life~24 h

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsAnecdotalEfficacyAnecdotalSideEffectsPrice3.01.73.53.82.73.0

Research Evidence

Evidence shape

MK-677 possesses low-tier clinical evidence, limited to exploratory human studies focused on diagnostic, mechanistic, and treatment-based applications. While six registered trials exist, only one has posted results, and the total human participant pool remains small at 49 subjects. The research landscape is characterized by a high withdrawal rate and a reliance on single-trial, long-tail indications such as chronic kidney disease, fibromyalgia, and cognitive function in aging. This lack of large-scale, blinded data means the current evidence base is insufficient to support broad clinical conclusions.

Depthhow much
6 registered trials
4 completed · 1 with posted results · combined n=49
Breadthhow many areas
8 indications mapped
6 thin / exploratory · 1 animal-only · 6 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
1 blinded with results · 3 distinct sponsors · 33% withdrawal rate · AE table from NCT00395291 · 2 linked publications on registered trials
Breadth and depth24 rows captured
Human
direct clinical signal
8
Animal
translational support
12
In vitro
mechanistic support
4
HighMediumLow

Anecdotal efficacy

MK-677 side effects

Clinical research side effects

Anecdotal side effects

Price

Full buying guide →
1
Disguisedalpha
US
102 mg
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50 mg
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25 mg
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25 mg
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25 mg
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Moglabs
US
25 mg
$68.00
$2.72/mg

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MK-677 dosing & protocol

How MK-677 is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 5
Typical dose
25 mg5 mg – 25 mg
typical
0
10 mg
20 mg
30 mg
distribution of 4 reported doses · darker = more
Frequency
daily
Route
oral

In the reported research trials, MK‑677 was administered orally at doses between 5 mg and 25 mg per day, with 25 mg daily being the most frequently used amount; no specific cycling schedule was described.

5 sources
Clinician practice
Doctor & published-protocol guidance
Typical dose
—
0
10 mg
20 mg
30 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

Anecdotal
Community-reported real-world use · n = 31
Typical dose
10 mg5 mg – 30 mg
typical
0
10 mg
20 mg
30 mg
distribution of 36 reported doses · darker = more
Frequency
unspecified
Route
oral
Cycle
~8-week cycle · 2 reports

Oral MK‑677 is typically taken around 10 mg, with reported doses ranging from 5 mg to 30 mg; most users dose continuously while a small minority (about 2 of 31 reports) follow an roughly 8‑week cycle.

31 sources

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