Semax

Semax is a synthetic ACTH-derived peptide, approved in Russia for neuroprotection and cognitive enhancement, and the community runs it mainly for cognitive enhancement, with a smaller group using it for focus and attention; reports are mixed to positive. There's no FDA-approved indication, and the human evidence outside Russia stays preliminary, so all use here is off-label or compounded. Most people dose around 300 micrograms a day, with reports ranging from 100 micrograms up to 20 mg, typically taken daily. Timing and cycling aren't well established in what people report.

Half-life~18 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.91.73.72.93.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

No CT.gov-registered trials for Semax, but 9 published human studies were extracted from the literature — peer-reviewed reports below, split into treatment vs diagnostic/mechanistic, not registry-grade evidence. Off-label / exploratory data exists for 2 additional indications (Treatment studies; Diagnostic & mechanistic studies).

Depthhow much
0 registered trials
Breadthhow many areas
3 indications mapped
2 thin / exploratory · 1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth22 rows captured
Human
direct clinical signal
9
Animal
translational support
12
In vitro
mechanistic support
1
HighMediumLow

Anecdotal efficacy

Semax side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

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USA
100 mg
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Bulk Peptide Supply
unknown
300 mg×10
$400.00
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GB
50 mg
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1-6 of 325

Semax dosing & protocol

How Semax is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 7
Typical dose
12 mg6 mg – 12 mg
typical
0
10 mg
20 mg
30 mg
distribution of 3 reported doses · darker = more
Frequency
daily

The trials used intranasal Semax at doses ranging from 6 mg to 12 mg taken once per day, with the most common regimen being 12 mg daily.

7 sources
Clinician practice
Doctor & published-protocol guidance · n = 1
Typical dose
600 µg200 µg – 600 µg
typical
0
10 mg
20 mg
30 mg
distribution of 3 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
intranasal

The clinician‑reported regimen uses 600 µg of Semax administered intranasally once each day, with a reported range of 200–600 µg daily, based on a single source. No specific cycling protocol was reported.

1 source
Anecdotal
Community-reported real-world use · n = 41
Typical dose
500 µg100 µg – 30 mg
typical
0
10 mg
20 mg
30 mg
distribution of 54 reported doses · darker = more
By stated route· tap a row to filter the chart
Frequency
unspecified

Community users report taking 1 mg of Semax intranasally, with amounts ranging from 100 mcg to 30 mg and no consistent frequency or cycling described.

41 sources

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