Semax

Semax is a synthetic ACTH analog that users most often take for cognitive enhancement and focus. Community reports show a typical dose of about 500 µg per day, though actual use ranges from 15 µg to 30 mg and most posts do not specify timing or cycling; clinician guidance, based on two sources, favors 200–600 µg intranasal daily, often in 20‑day on, 10‑day off cycles. The off‑label evidence base is thinner than the discussion implies, with most exploratory uses lacking posted results.

Half-life~18 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.91.73.72.93.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

Semax has limited human evidence, consisting of nine published studies—seven exploring treatment uses and two examining diagnostic or mechanistic roles. Although the thin indications together account for nine human studies, they map onto three indications—two thin/exploratory human areas (treatment and diagnostic/mechanistic) and one animal‑only preclinical area—and no clinical trials have been registered or completed. As a result, the data stay preliminary, with no posted trial results to support any clinical claim.

Depthhow much
0 registered trials
Breadthhow many areas
3 indications mapped
2 thin / exploratory · 1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth22 rows captured
Human
direct clinical signal
9
Animal
translational support
12
In vitro
mechanistic support
1
HighMediumLow

Anecdotal efficacy

Semax side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

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SEMAX dosing & protocol

How SEMAX is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 7
Typical dose
12 mg6 mg – 12 mg
typical
0
10 mg
20 mg
30 mg
distribution of 3 reported doses · darker = more
Frequency
daily
Route
intranasal

In the research‑trial tier, SEMAX was given intranasally at 6 mg–12 mg once daily, with the most frequent regimen being 12 mg per day; no cycling schedule was specified.

7 sources
Clinician practice
Doctor & published-protocol guidance · n = 1
Typical dose
600 µg200 µg – 600 µg
typical
0
10 mg
20 mg
30 mg
distribution of 3 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
intranasal

In clinician practice, SEMAX is commonly given intranasally at 600 mcg once daily, with reported doses ranging from 200 mcg to 600 mcg per day.

1 source
Anecdotal
Community-reported real-world use · n = 58
Typical dose
500 µg15 µg – 30 mg
typical
0
10 mg
20 mg
30 mg
distribution of 74 reported doses · darker = more
By stated route· tap a row to filter the chart
Frequency
unspecified
Route
intranasal

Community users typically administer 500 mcg intranasally; frequency is not specified and doses reported span widely from 15 mcg up to 30 mg.

58 sources

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