Diagnostic & mechanistic studies
tested resting-state fMRI functional connectivity of amygdala and DLPFC ROIs at 5 and 20 min post-injection
result Between-group FC differences found between right amygdala and right temporal cortex (fusiform, inferior/middle temporal, parahippocampal gyri); Selank and Semax showed both shared and distinct FC patterns vs placebo.
Published human study (PubMed / Europe PMC), extracted from its abstract — not a CT.gov-registered trial.
Treatment studies
tested anxiety and asthenia symptoms (Hamilton, Zung, CGI scales); tau(1/2) leu-enkephalin serum levels
result Selank (n=30) vs medazepam (n=32): similar anxiolytic effects; selank also produced antiasthenic and psychostimulant effects; increased tau(1/2) leu-enkephalin, especially in GAD patients.
Published human study (PubMed / Europe PMC), extracted from its abstract — not a CT.gov-registered trial.
Treatment studies
tested Th1/Th2 cytokine balance in serum; IL-6 gene expression and concentration in peripheral blood cell cultures
result Selank (14 days in vivo) produced significant shifts in Th1/Th2 cytokine balance with inverse correlation dynamics; in vitro 10-7 M suppressed IL-6 gene expression in depression patients but increased IL-6 concentration (p<0.05).
Published human study (PubMed / Europe PMC), extracted from its abstract — not a CT.gov-registered trial.
Treatment studies
tested anxiolytic effect, nootropic effect, quality of life, tolerability
result Pronounced anxiolytic and mild nootropic effects demonstrated; anxiolytic effect persisted for 1 week after last dose; positive impact on quality of life reported.
Published human study (PubMed / Europe PMC), extracted from its abstract — not a CT.gov-registered trial.
Treatment studies
tested HDRS, CGI, Spilberger scales; UKU tolerability scale; Stroop test; verbal fluency; SF-36 quality of life
result Selank add-on (n=40) vs phenazepam monotherapy (n=30): earlier anxiolytic effect on HDRS; reduced phenazepam side-effects (attention/memory impairment, sedation, sexual disturbances, orthostatism); better quality of life.
Published human study (PubMed / Europe PMC), extracted from its abstract — not a CT.gov-registered trial.
Preclinical / mechanistic research
tested rat · [Effect of new synthetic anxiolytic selank on gastric wall blood flow and mesenteryc lymphatic vessels contractility in anesthetized rats].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · [Compensatory effect of selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of the rat brain].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · [Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · [Effect of selank on the main carboxypeptidases in the rat nervous tissue].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · [The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity].
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.