Preclinical / mechanistic research
tested mouse · Bone architecture and disc degeneration in the lumbar spine of mice lacking GDF-8 (myostatin). (PMID 14554215 · DOI 10.1016/s0736-0266(03)00105-0)
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · Craniofacial morphology in myostatin-deficient mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · Age-related changes in craniofacial morphology in GDF-8 (myostatin)-deficient mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · GDF8 inhibits bone formation and promotes bone resorption in mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · Expression and significance of related genes in the early stage of post-traumatic heterotopic ossification in a rat model of Achilles tenotomy.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · CRISPR/Cas9-Targeted <i>Myostatin</i> Deletion Improves the Myogenic Differentiation Parameters for Muscle-Derived Stem Cells in Mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primates.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested rat · Effect of high-intensity interval training and resistance training on the follistatin and myostatin levels in gastrocnemius muscle of aged female rats.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · Effect of Goat Meat on Muscle Atrophy Induced by Dexamethasone in Mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested mouse · Active immunization against myostatin and activin A improves skeletal muscle performance in growth hormone-deficient mice.
result Preclinical publication captured from PubMed/Europe PMC; effect details require paper-level extraction.
Preclinical / mechanistic research
tested Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb.
result In-vitro publication captured from PubMed/Europe PMC; assay details require paper-level extraction.
Preclinical / mechanistic research
tested Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability.
result In-vitro publication captured from PubMed/Europe PMC; assay details require paper-level extraction.
Preclinical / mechanistic research
tested GDF8 activates p38 MAPK signaling during porcine oocyte maturation in vitro.
result In-vitro publication captured from PubMed/Europe PMC; assay details require paper-level extraction.
Preclinical / mechanistic research
tested GDF-8 improves <i>in vitro</i> implantation and cryo-tolerance by stimulating the ALK5-SMAD2/3 signaling in bovine IVF embryo development.
result In-vitro publication captured from PubMed/Europe PMC; assay details require paper-level extraction.