Tesofensine

Tesofensine is a triple reuptake inhibitor originally developed for neurodegenerative conditions that is now used off-label for weight loss, appetite suppression, and cognitive support. Users typically run doses ranging from 100 µg to 15 mg daily, with 250 µg serving as the most common intake. While sleep and dream disturbances are occasionally reported, injection-site reactions and gastrointestinal issues have not been a consistent theme. The primary tradeoff for users is that the evidence base for these applications remains thin, as the substance lacks FDA approval and most exploratory trials have not yielded publicly available results.

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsAnecdotalEfficacyAnecdotalSideEffectsPrice3.21.31.64.13.22.0

Research Evidence

Evidence shape

Tesofensine has moderate evidence, with one published human study on treatment. The research spans 10 indications, including obesity and Parkinson's disease, with four blinded trials and results from distinct sponsors. Most indications have limited exploration, with many having only single trials and some lacking posted results.

Depthhow much
11 registered trials
11 completed · 4 with posted results · combined n=159
Breadthhow many areas
10 indications mapped
9 thin / exploratory · 1 animal-only · 7 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
4 blinded with results · 4 distinct sponsors · AE rows aggregated from 2 trials · 3 linked publications on registered trials
Breadth and depth20 rows captured
Human
direct clinical signal
12
Animal
translational support
8
In vitro
mechanistic support
0
HighMediumLow

Anecdotal efficacy

Tesofensine side effects

Clinical research side effects

Anecdotal side effects

Price

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Tesofensine dosing & protocol

How Tesofensine is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 11
Typical dose
500 µg500 µg – 1 mg
typical
0
5 mg
10 mg
15 mg
distribution of 2 reported doses · darker = more
Frequency
daily
Route
oral

Trials administered tesofensine orally at 500 mcg daily, with at least one pharmacokinetic study using 1 mg; the documented range across the trial record runs 500 mcg to 1 mg. No cycling protocol is captured in this evidence set.

11 sources
Clinician practice
Doctor & published-protocol guidance
Typical dose
—
0
5 mg
10 mg
15 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

Anecdotal
Community-reported real-world use · n = 32
Typical dose
250 µg100 µg – 15 mg
typical
0
5 mg
10 mg
15 mg
distribution of 41 reported doses · darker = more
Frequency
unspecified
Route
oral

Community accounts — 32 in total — report taking 250 mcg orally as a common dose, with individual examples spanning roughly 125 mcg to 1 mg. Only a handful name daily dosing explicitly; most reports omit cadence, and no cycling pattern appears in the data.

32 sources

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