Melanotan II

Melanotan II is a synthetic melanocortin peptide that community users most often take for skin tanning and pigmentation, with notable off‑label interest in libido enhancement and appetite suppression. Community reports cluster around 500 µg taken daily, though individual use spans from 40 µg to 4 mg per day; clinicians who guide its use typically recommend 100–250 µg per day, often in 4‑ to 6‑week cycles. The peptide carries no FDA‑approved indication, meaning all human use is off‑label or compounded and the evidence base remains thin.

Half-life~1 h

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.61.73.83.05.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

Human evidence for Melanotan II is limited — pilot studies, withdrawn trials, or completed trials without posted results. Off-label / exploratory data exists for 1 additional indication (NonSegmental Vitiligo).

Depthhow much
1 registered trial
1 recruiting / active
Breadthhow many areas
2 indications mapped
1 thin / exploratory · 1 animal-only · 1 single-trial long-tail
Qualityhow rigorous
No completed trials
Breadth and depth21 rows captured
Human
direct clinical signal
1
Animal
translational support
12
In vitro
mechanistic support
8
HighMediumLow

Anecdotal efficacy

Melanotan II side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

Full buying guide →
1
Bodylab
GB
500 mg
$28.52
$0.054/mg
2
Disguisedalpha
US
548 mg
$54.99
$0.1/mg
3
Peptide Pros
--
30 mg
$7.50
$0.25/mg
4
High Purity Peptides
Hong Kong
100 mg×10
$50.00
$0.5/mg
5
Uther
unknown
100 mg×10
$60.00
$0.6/mg
6
HKRoids
Hong Kong
100 mg×10
$63.00
$0.63/mg

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Melanotan II dosing & protocol

How Melanotan II is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols
Typical dose
—
0
1 mg
2 mg
3 mg
4 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

No completed trials were identified for this peptide, so the research‑trial tier provides no reliable dose amount, frequency, or cycling information.

Clinician practice
Doctor & published-protocol guidance · n = 1
Typical dose
250 µg100 µg – 250 µg
typical
0
1 mg
2 mg
3 mg
4 mg
distribution of 3 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
subQ

One clinician source places the dose at 100–250 mcg subcutaneously, daily, with 250 mcg as the typical target.

1 source
Anecdotal
Community-reported real-world use · n = 50
Typical dose
500 µg40 µg – 4 mg
typical
0
1 mg
2 mg
3 mg
4 mg
distribution of 61 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
mixed
Route
subQ

Most community reports cite a typical dose of 500 mcg without a specified schedule, while a smaller group doses daily (usually 100 mcg) and even fewer follow weekly or other intermittent patterns.

50 sources

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