Melanotan II

Melanotan II is a synthetic melanocortin peptide that people primarily use to induce skin tanning, boost libido, and suppress appetite. In the community the most common regimen is about 500 µg daily, with reported doses ranging from 40 µg to 4 mg, while clinicians who prescribe it tend to use 100–250 µg daily subcutaneously for 4–6‑week cycles. The evidence base is thin and entirely off‑label, and users occasionally report nausea, mild injection‑site irritation, or disrupted sleep/dreams, with no consistent reports of flushing or edema.

Half-life~1 h

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.61.73.83.04.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

The evidence for Melanotan II is limited to animal studies, with no human published studies. There is one registered trial, which is currently recruiting, and two indications have been mapped, including NonSegmental Vitiligo with one trial. The lack of completed trials and human published studies indicates a low evidence tier, with most research being exploratory or preclinical.

Depthhow much
1 registered trial
1 recruiting / active
Breadthhow many areas
2 indications mapped
1 thin / exploratory · 1 animal-only · 1 single-trial long-tail
Qualityhow rigorous
No completed trials
Breadth and depth21 rows captured
Human
direct clinical signal
1
Animal
translational support
12
In vitro
mechanistic support
8
HighMediumLow

Anecdotal efficacy

Melanotan II side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

Full buying guide →
1
Disguisedalpha
US
548 mg
$54.99
$0.1/mg
2
Peptide Pros
--
30 mg
$7.50
$0.25/mg
3
Mrbeetoe
--
100 mg
$65.00
$0.65/mg
4
Bio Hack London
GB
100 mg
$79.19
$0.792/mg
5
Northwest Peptides
--
10 mg
$7.99
$0.8/mg
6
peptidesourcehub.com
--
100 mg
$79.90
$0.8/mg

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Melanotan II dosing & protocol

How Melanotan II is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols
Typical dose
—
0
200 µg
400 µg
600 µg
800 µg
1 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

No completed trials were identified for this peptide, so the research‑trial tier provides no reliable dose amount, frequency, or cycling information.

Clinician practice
Doctor & published-protocol guidance · n = 1
Typical dose
250 µg100 µg – 250 µg
typical
0
200 µg
400 µg
600 µg
800 µg
1 mg
distribution of 3 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
subQ

One clinician source places the dose at 100–250 mcg subcutaneously, daily, with 250 mcg as the typical target.

1 source
Anecdotal
Community-reported real-world use · n = 10
Typical dose
500 µg100 µg – 1 mg
typical
0
200 µg
400 µg
600 µg
800 µg
1 mg
distribution of 14 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
mostly daily
Route
subQ

Among 52 community reports, 500 mcg subQ is the typical dose, though the range runs from 40 mcg to 4 mg. Most reporters didn't specify a schedule; of those who did, daily was the most common cadence, with a smaller group dosing weekly.

10 sources

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