Kisspeptin-10

Kisspeptin‑10 is a decapeptide that activates KISS1R to drive the HPG axis and is run off‑label for hormone regulation, libido enhancement, and LH‑pulse stimulation, with a single infertility trial supporting an FDA label. Community users typically inject 200 µg daily (range 100–400 µg), while clinician‑sourced protocols advise 50–200 µg per day, often split BID, with cycles of two to four weeks. The most notable drawback is a roughly 19 % withdrawal rate observed across the registered trial program; side effects are limited, with occasional reports of altered sleep or vivid dreams and rare injection‑site irritation.

Half-life~6 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsAnecdotalEfficacyAnecdotalSideEffectsPrice3.12.83.22.93.23.0

Research Evidence

Evidence shape

The evidence for kisspeptin-10 is moderate, primarily supporting treatment studies and diagnostic or mechanistic research in humans. Four treatment studies and eighteen diagnostic or mechanistic studies have been published, covering indications like infertility, hypogonadotropic hypogonadism, and reproductive disorder. Among registered trials, ten are completed with four posting results, and the highest-quality data come from two blinded Phase 2 trials run by three distinct sponsors, though nearly one in five trials were withdrawn.

Depthhow much
16 registered trials
10 completed · 4 with posted results · 3 recruiting / active · combined n=245
Breadthhow many areas
12 indications mapped
1 with results · 8 thin / exploratory · 1 animal-only · 5 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
2 blinded with results · 3 distinct sponsors · 19% withdrawal rate · AE rows aggregated from 3 trials · 13 linked publications on registered trials
Breadth and depth57 rows captured
Human
direct clinical signal
38
Animal
translational support
12
In vitro
mechanistic support
7
HighMediumLow

Anecdotal efficacy

Kisspeptin-10 side effects

Clinical research side effects

Anecdotal side effects

Price

Full buying guide →
1
Treasure Coast Peptides
--
100 mg
$38.00
$0.38/mg
2
Disguisedalpha
US
102 mg
$54.99
$0.539/mg
3
Uther
unknown
100 mg×10
$80.00
$0.8/mg
4
High Purity Peptides
Hong Kong
100 mg×10
$90.00
$0.9/mg
5
Saiyan Med
US
100 mg×10
$130.00
$1.3/mg
6
Nurev Peptides
--
10 mg
$13.99
$1.4/mg

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Kisspeptin-10 dosing & protocol

How Kisspeptin-10 is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 14
Typical dose
1.0 mg
typical
0
500 µg
1 mg
1.5 mg
across 1 dosed source · darker = more agree
Frequency
continuous
Route
subQ

In the research trials, Kisspeptin‑10 was administered subcutaneously at a fixed 1.0 mg dose continuously; some studies used a weight‑based range of 0.313–40 µg/kg, with no cycling protocol reported.

14 sources
Clinician practice
Doctor & published-protocol guidance · n = 2
Typical dose
100 µg50 µg – 200 µg
typical
0
500 µg
1 mg
1.5 mg
distribution of 4 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
twice daily
Route
subQ

Subcutaneous Kisspeptin-10 is typically given at 50 mcg to 200 mcg, most often as 100 mcg twice daily or 200 mcg once daily according to available clinician reports.

2 sources
Anecdotal
Community-reported real-world use · n = 12
Typical dose
200 µg100 µg – 400 µg
typical
0
500 µg
1 mg
1.5 mg
distribution of 17 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
mixed
Route
subQ

Most users administer Kisspeptin‑10 subcutaneously without a set schedule, typically around 200 mcg (range 100–400 mcg), while a smaller group doses daily or weekly.

12 sources

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