Kisspeptin-10

Kisspeptin-10 is a short-chain peptide fragment that activates the GPR54 receptor to regulate the HPG axis, primarily utilized off-label for hormone regulation and libido enhancement. Users typically run daily doses ranging from 100 µg to 400 µg, while clinician-tier protocols suggest 50 µg to 200 µg administered subcutaneously. Reports of altered sleep and vivid dreams occasionally surface, though injection-site reactions are rarely noted. Readers should be aware that the off-label evidence base is thinner than common discourse suggests, with most exploratory indications lacking posted results and a 19% withdrawal rate observed across the registered trial program.

Half-life~6 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsAnecdotalEfficacyAnecdotalSideEffectsPrice3.12.83.42.93.23.0

Research Evidence

Evidence shape

Kisspeptin-10 possesses moderate human evidence, primarily centered on diagnostic and mechanistic research regarding reproductive function. While 22 published studies exist, the clinical literature remains fragmented, with only two blinded trials reporting results across 16 registered studies and a 19% withdrawal rate. Most of the 12 mapped indications, including hypogonadotropic hypogonadism and hypothalamic amenorrhea, rely on thin or exploratory data, leaving the majority of its potential therapeutic applications in a long-tail state without robust, large-scale validation.

Depthhow much
16 registered trials
10 completed · 3 with posted results · 3 recruiting / active · combined n=227
Breadthhow many areas
12 indications mapped
1 with results · 8 thin / exploratory · 1 animal-only · 5 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
2 blinded with results · 3 distinct sponsors · 19% withdrawal rate · AE rows aggregated from 2 trials · 13 linked publications on registered trials
Breadth and depth58 rows captured
Human
direct clinical signal
38
Animal
translational support
12
In vitro
mechanistic support
8
HighMediumLow

Anecdotal efficacy

Kisspeptin-10 side effects

Clinical research side effects

Anecdotal side effects

Price

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KISSPEPTIN-10 dosing & protocol

How KISSPEPTIN-10 is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 14
Typical dose
1.0 mg
typical
0
500 µg
1 mg
1.5 mg
across 1 dosed source · darker = more agree
Frequency
continuous
Route
subQ

In the trial tier, Kisspeptin‑10 was administered subcutaneously at a fixed dose of 1.0 mg continuously; some studies used weight‑based dosing of 0.313–40 mcg/kg.

14 sources
Clinician practice
Doctor & published-protocol guidance · n = 2
Typical dose
100 µg50 µg – 200 µg
typical
0
500 µg
1 mg
1.5 mg
distribution of 4 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
twice daily
Route
subQ

Clinician protocols dose 50 µg–200 µg twice daily subQ (2 sources).

2 sources
Anecdotal
Community-reported real-world use · n = 11
Typical dose
200 µg100 µg – 400 µg
typical
0
500 µg
1 mg
1.5 mg
distribution of 15 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
mixed
Route
subQ

Most users (9 of 16) report no set cadence, taking about 100 µg per injection, with doses ranging from 100 µg to 10 mg. Smaller groups use 200 µg 3 times per week (3 users), 200 µg weekly (3 users), or 100 µg 3 times daily (1 user).

11 sources

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