FOXO4-DRI

FOXO4-DRI is a D-retro-inverso peptide that disrupts the FOXO4-p53 interaction, and people run it as a senolytic to clear senescent cells, with a smaller set using it for anti-aging and longevity broadly. The most common community dose is 10 milligrams daily, and clinician protocols land in the 5–10 milligram range, dosed subcutaneously in short cycles of two to six weeks. There is no FDA-approved indication; all human use is off-label or compounded, and the supporting evidence remains animal-only. Report volume is still low, so both the efficacy and safety picture should be read as preliminary.

Half-life~24 h

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyno dataClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice0.43.13.13.0

Measured on 4 of 6 axes

Research Evidence

Evidence shape

FOXO4-DRI currently exists strictly within the realm of animal-only research, with no published human trials or clinical data available. The existing evidence is limited to preclinical and mechanistic studies, providing no basis for human efficacy or safety profiles. Because there are zero registered trials and no completed human studies, the peptide lacks the necessary data to support any therapeutic application. This absence of human-grade evidence means that all current understanding of the peptide remains confined to laboratory models.

Depthhow much
0 registered trials
Breadthhow many areas
1 indication mapped
1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth18 rows captured
Human
direct clinical signal
0
Animal
translational support
10
In vitro
mechanistic support
8
HighMediumLow

Anecdotal efficacy

FOXO4-DRI side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

Full buying guide →
1
HKRoids
Hong Kong
100 mg×10
$45.00
$0.45/mg
2
Prism Aminos
US
10 mg
$5.00
$0.5/mg
3
Nuvena Peptides
--
10 mg
$55.00
$5.5/mg
4
peptidesourcehub.com
--
100 mg
$599.90
$6/mg
5
Bulk Peptide Supply
unknown
100 mg×10
$650.00
$6.5/mg
6
Raccoon Peptides
GB
10 mg
$66.44
$6.64/mg

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FOXO4-DRI dosing & protocol

How FOXO4-DRI is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols
Typical dose
—
0
5 mg
10 mg
15 mg
20 mg
25 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

Clinician practice
Doctor & published-protocol guidance · n = 2
Typical dose
10 mg5 mg – 10 mg
typical
0
5 mg
10 mg
15 mg
20 mg
25 mg
distribution of 2 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
subQ

Clinician practice reports subcutaneous dosing of FOXO4‑DRi at 5 mg to 10 mg taken once daily, with some users opting for the lower 5 mg dose and others the full 10 mg.

2 sources
Anecdotal
Community-reported real-world use · n = 18
Typical dose
3 mg350 µg – 25 mg
typical
0
5 mg
10 mg
15 mg
20 mg
25 mg
distribution of 18 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
mixed
Route
subQ

Anecdotal users of FOXO4‑DRI most often report 25 mg subcutaneously, with one taking it every other day and another taking 2 mg daily; two reports gave no frequency, and no cycling pattern was mentioned.

18 sources

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