Epithalon

Epithalon is a synthetic tetrapeptide derived from pineal gland extract, associated with telomere elongation, anti-aging, and sleep regulation; in practice, sleep and circadian rhythm is what most people run it for, with a smaller longevity-focused thread. Community dosing runs from 250 mcg to 5 mg, most commonly 500 mcg daily, while clinician protocols run higher at 1 mg to 10 mg subcutaneously. The tradeoff to know up front: there is no FDA-approved indication, so all human use is off-label or compounded. Effects on sleep and dreams are the dominant reported experience, and not everyone finds them positive.

Half-life~3 h

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.81.73.63.24.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

The evidence for Epithalon is limited, with around 14 human published studies focused on treatment. These studies cover a narrow range of indications, with no completed trials and no blinded results reported. The research is largely exploratory, with some indications studied only in animals or at a preclinical level, indicating a need for more robust and comprehensive investigation.

Depthhow much
0 registered trials
Breadthhow many areas
2 indications mapped
1 thin / exploratory · 1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth38 rows captured
Human
direct clinical signal
14
Animal
translational support
12
In vitro
mechanistic support
12
HighMediumLow

Anecdotal efficacy

Epithalon side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

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1
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US
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GB
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EPITHALON dosing & protocol

How EPITHALON is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 14
Typical dose
100 mg
typical
0
20 mg
40 mg
60 mg
80 mg
100 mg
across 1 dosed source · darker = more agree
Frequency
daily

In the research trials examined, Epithalon was given at a fixed dose of 100 mg taken daily; no specific cycling regimen was documented across the studies.

14 sources
Clinician practice
Doctor & published-protocol guidance · n = 3
Typical dose
5 mg1 mg – 10 mg
typical
0
20 mg
40 mg
60 mg
80 mg
100 mg
distribution of 5 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
subQ

Clinicians most often use 5 mg subcutaneously each day, with a reported range of 1 mg to 10 mg; a once‑weekly 1 mg subcutaneously dose is also noted.

3 sources
Anecdotal
Community-reported real-world use · n = 36
Typical dose
500 µg100 µg – 50 mg
typical
0
20 mg
40 mg
60 mg
80 mg
100 mg
distribution of 40 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
subQ

Most users report an unstated schedule, typically around 500 mcg, while a smaller group doses daily at about 500 mcg; no cycling pattern is reported.

36 sources

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