5-Amino-1MQ

5‑Amino‑1MQ is a selective NNMT inhibitor that the community uses off‑label to promote fat loss and improve body composition, with most users reporting positive effects. The prevailing regimen is an oral dose of about 50 mg per day, often split into two doses, and typically cycled for two to four weeks; clinician‑derived protocols echo the same daily amount. Because it has no FDA‑approved indication, all human use is off‑label or compounded, and injection‑site reactions have not emerged as a consistent concern.

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyno dataClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice0.43.53.25.0

Measured on 4 of 6 axes

Research Evidence

Evidence shape

5-Amino-1MQ currently exists as an animal-only research compound with no published human clinical trials. The existing literature is restricted to preclinical and mechanistic studies, meaning there is no data regarding safety, efficacy, or optimal dosing in human subjects. Because no registered trials have been completed or published, the peptide lacks the foundational evidence required to support its use for any specific indication.

Depthhow much
0 registered trials
Breadthhow many areas
1 indication mapped
1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth11 rows captured
Human
direct clinical signal
0
Animal
translational support
7
In vitro
mechanistic support
4
HighMediumLow

Anecdotal efficacy

1
unknown
500 mg×10
$36.00
$0.07/mg
2
GB
50 mg
$5.03
$0.094/mg
3
--
1250 mg×25
$120.00
$0.1/mg
4
--
50 mg
$13.99
$0.28/mg
5
US
500 mg×10
$336.00
$0.67/mg
6
--
100 mg
$79.00
$0.79/mg

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5-Amino-1MQ dosing & protocol

How 5-Amino-1MQ is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols
Typical dose
0
10 mg
20 mg
30 mg
40 mg
50 mg
no dose captured for this tier yet

No structured protocol details captured for this tier yet.

Clinician practice
Doctor & published-protocol guidance · n = 1
Typical dose
2.5 mg
typical
0
10 mg
20 mg
30 mg
40 mg
50 mg
across 1 dosed source · darker = more agree
By reported cadence
Twice daily2.5 mg · n=1
Frequency
twice daily
Route
subQ

In the clinician tier, the recommended dose is 2.5 mg of 5‑Amino‑1MQ given subcutaneously twice daily, with no defined cycling schedule provided in the source.

1 source
Anecdotal
Community-reported real-world use · n = 42
Typical dose
5 mg250 µg – 50 mg
typical
0
10 mg
20 mg
30 mg
40 mg
50 mg
distribution of 49 reported doses · darker = more
By reported cadence· tap a row to filter the chart
By stated route· tap a row to filter the chart
Frequency
daily
Route
oral
Cycle
5 days on / 2 days off · 2 reports

Most users take an unspecified amount (typically around 5 mg) without a set schedule, while a smaller group doses daily (often 50 mg); the majority use it continuously, with only a few reporting a 5‑days‑on/2‑days‑off cycle.

42 sources