Pinealon

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) originally derived from the pineal gland, studied for neuroprotection, cognitive enhancement, and circadian rhythm regulation. Community dosing spans 100 µg to 5 mg, most commonly 2 mg and most often daily. It has no FDA-approved indication, so all human use is off-label or compounded, and the evidence to date is confined to preclinical and mechanistic research.

Half-life~30 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsno dataAnecdotalEfficacyAnecdotalSideEffectsPrice1.71.73.43.13.0

Measured on 5 of 6 axes

Research Evidence

Evidence shape

Pinealon possesses a low tier of evidence, supported only by four exploratory human treatment studies and a collection of preclinical research. The existing literature lacks the rigor of registered, blinded clinical trials, leaving the peptide’s efficacy for its mapped indications unverified by large-scale human data. Because no completed trials exist to substantiate these early findings, the current research remains limited to preliminary observations that have not progressed to formal clinical validation.

Depthhow much
0 registered trials
Breadthhow many areas
2 indications mapped
1 thin / exploratory · 1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth17 rows captured
Human
direct clinical signal
4
Animal
translational support
11
In vitro
mechanistic support
2
HighMediumLow

Anecdotal efficacy

Pinealon side effects

Clinical research side effects

Grouped from 2 published human studies — weighted by study count, not incidence (the papers report no rates).

Anecdotal side effects

Price

Full buying guide →
1
Disguisedalpha
US
102 mg
$69.99
$0.686/mg
2
Mrbeetoe
--
50 mg
$50.00
$1/mg
3
Offline Peptides
--
20 mg
$25.00
$1.25/mg
4
Elite Aminos LLC
--
20 mg
$32.00
$1.6/mg
5
Purerxpeptides
US
20 mg
$32.00
$1.6/mg
6
Bulk Peptide Supply
unknown
200 mg×10
$350.00
$1.75/mg

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1-6 of 111

PINEALON dosing & protocol

How PINEALON is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 4
Typical dose
100 µg
typical
0
1 mg
2 mg
3 mg
across 1 dosed source · darker = more agree
Frequency
twice daily
Route
subQ

Only one of the four trial sources specified a dose, reporting Pinealon administered subcutaneously at 100 mcg twice daily, according to the data.

4 sources
Clinician practice
Doctor & published-protocol guidance · n = 2
Typical dose
1 mg
typical
0
1 mg
2 mg
3 mg
distribution of 2 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
daily
Route
subQ

The clinician practice tier prescribes Pinealon at a fixed dose of 1 mg given subcutaneously on a daily basis, with no reported cycling schedule.

2 sources
Anecdotal
Community-reported real-world use · n = 12
Typical dose
1 mg100 µg – 3 mg
typical
0
1 mg
2 mg
3 mg
distribution of 19 reported doses · darker = more
By reported cadence· tap a row to filter the chart
Frequency
mostly daily
Route
subQ

Most users report taking 1 mg of PINEALON subcutaneously, with a range from 100 µg to 3 mg; among those who specified frequency, four dose daily and one doses twice daily.

12 sources

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