Glutathione

Glutathione is the body's primary endogenous antioxidant, and people run it mostly for skin health and appearance, with steady followings for detoxification, liver support, and neurological benefit. Community dosing centers on about 2.5 milligrams daily across a wide reported range, while clinician protocols run far higher, around 200 milligrams twice daily by mouth. Sleep and dream changes occasionally surface in user reports, but no other consistent side-effect pattern has emerged. The honest caveat: outside a couple of narrow tested settings, the off-label evidence base is thinner than the discourse suggests, spread across many indications each backed by only one or two small trials, often without posted results.

Half-life~14 min

Data last updated

ClinicalResearchDepthClinicalResearchEfficacyClinicalResearchSideEffectsAnecdotalEfficacyAnecdotalSideEffectsPrice3.11.33.03.92.85.0

Research Evidence

Evidence shape

Glutathione possesses low-tier clinical evidence, consisting primarily of exploratory human studies rather than large-scale, definitive trials. While 26 published studies exist across 16 distinct indications, the research remains fragmented, with 12 of these indications supported by only a single trial. The highest quality evidence reaches Phase 2, yet the lack of robust, multi-trial validation across these diverse conditions signals that the current literature is largely preliminary and insufficient to establish standardized therapeutic efficacy.

Depthhow much
18 registered trials
12 completed · 1 with posted results · 2 recruiting / active · combined n=60
Breadthhow many areas
18 indications mapped
16 thin / exploratory · 1 animal-only · 13 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
1 blinded with results · 11 distinct sponsors · AE table from NCT03020719 · 4 linked publications on registered trials
Breadth and depth68 rows captured
Human
direct clinical signal
44
Animal
translational support
12
In vitro
mechanistic support
12
HighMediumLow

Anecdotal efficacy

1
--
1500 mg
$20.00
$0.01/mg
2
--
15000 mg
$90.00
$0.01/mg
3
GB
1500 mg
$20.00
$0.01/mg
4
--
1500 mg
$13.99
$0.01/mg
5
--
1500 mg
$20.00
$0.01/mg
6
GB
1500 mg
$26.83
$0.013/mg

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Glutathione dosing & protocol

How Glutathione is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 23
Typical dose
250 mg5 mg – 1000 mg
typical
0
200 mg
400 mg
600 mg
800 mg
1000 mg
distribution of 7 reported doses · darker = more
Frequency
daily
Route
oral

In research trials, glutathione was given orally at 250 mg once daily, with reported doses ranging from 5 mg to 1 g daily, and one study used 65 mg/kg per day.

23 sources
Clinician practice
Doctor & published-protocol guidance
Typical dose
200 mg
typical
0
200 mg
400 mg
600 mg
800 mg
1000 mg
single reported dose
Frequency
twice daily
Route
sublingual

The clinician tier reports a dose of 200 mg taken sublingual twice daily, with no specified cycling regimen for this tier.

Anecdotal
Community-reported real-world use · n = 2
Typical dose
50 mg
typical
0
200 mg
400 mg
600 mg
800 mg
1000 mg
distribution of 2 reported doses · darker = more
Frequency
unspecified
Route
subQ

Users report 50 mg subQ glutathione, with one source noting twice‑daily administration and another not specifying frequency; both used subcutaneous injection.

2 sources